https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Vancomycin therapeutic drug monitoring in paediatrics https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46792 400. Studies in children have shown that target trough concentrations poorly correlate to AUC/MIC > 400; however, they are used in practice for clinical convenience. This review in paediatric inpatients aims to audit performance against TDM guidelines and consider what changes are needed to optimise vancomycin monitoring. Methods: Vancomycin prescriptions in patients younger than 18 years old were collected over a 15-month period. Primary outcome measures were vancomycin initial dose (mg/kg/day) and the timing and result of first trough concentration (mg/L). Secondary outcome measures were the numbers achieving recommended targets and whether appropriate dose adjustments were made in response to TDM. Results: A total of 133 courses reached the time when TDM should occur. Average patient age was 6.5 years, and the average initial dose was 52.55 mg/kg/day (range 19.05–86.54 mg/kg). Only 25% of courses (n = 34) had a trough concentration measured at the recommended time. The mean trough concentration was 11.6 mg/L (range < 2.0–39.7). Of 40 patients with a low trough concentration, 50% continued without dose adjustment. Conclusion: As shown in the literature, there is a poor correlation between the vancomycin dose given and the trough concentration achieved. Given that recommendations for trough concentration monitoring are designed to simplify the process yet are poorly adhered to, a strategic plan to address these issues is needed.]]> Wed 30 Nov 2022 13:21:50 AEDT ]]> Evidence for microbiological influenced longer-term corrosion in tidal and coastal atmospheric corrosion of steel elements https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6035 Wed 11 Apr 2018 13:44:47 AEST ]]> Investigation of the total petroleum hydrocarbon degrading microorganisms in soil and water: a metagenomic approach https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27498 Wed 11 Apr 2018 09:37:47 AEST ]]> Engineering geology of the Richmond river estuary https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14058 Wed 11 Apr 2018 09:29:33 AEST ]]> Utility of blood cultures in children admitted to hospital with community-acquired pneumonia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31019 Wed 06 Apr 2022 13:59:07 AEST ]]> Data descriptor: systematic, continental scale temporal monitoring of marine pelagic microbiota by the Australian Marine Microbial Biodiversity Initiative https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39166 Tue 14 Nov 2023 12:24:12 AEDT ]]> Alterations in amino acid metabolism during growth by Staphylococcus aureus following exposure to H2O2 – A multifactorial approach https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43108 Tue 13 Sep 2022 13:22:24 AEST ]]> The Impact of Dietary Interventions on the Microbiota in Inflammatory Bowel Disease: A Systematic Review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55623 Tue 11 Jun 2024 16:02:37 AEST ]]> Toward a framework for predicting structural decay on coral reefs following extreme marine heatwaves https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55435 Thu 30 May 2024 14:19:29 AEST ]]> Rhizodegradation of PAHs differentially altered by C3 and C4 plants https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45322 Thu 27 Oct 2022 07:48:14 AEDT ]]> The rescue of replication forks stalled by nucleoproteins in E. coli https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35350 Thu 01 Aug 2019 16:09:05 AEST ]]> Coagulase-negative staphylococcal membrane-damaging toxins, pain intensity, and metabolic changes in temporomandibular disorder patients with chronic muscle pain https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1674 Sat 24 Mar 2018 08:30:25 AEDT ]]> Role of density in aggregation patterns and synchronization of spawning in the hermaphroditic scallop Pecten fumatus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19753 Sat 24 Mar 2018 07:54:28 AEDT ]]> Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: an observational cross-over study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37705 2.5 cfu/cm2 to indicate hygiene failure. Results: There were low levels of microbial contamination in the unit for baseline; DHP; and no DHP phases: 2.2% (95% CI 0.7-5.4%) vs 7.7% (95% CI 4.3-13.0%) vs 6% (95% CI 3.2-10.4%) hygiene failures, respectively. Significant reduction in ACCs did not occur when the DHP was operating compared with baseline and control phases. Conclusion: Further work is needed to determine whether continuous DHP technology has a role in decontamination for healthcare settings.]]> Mon 22 Mar 2021 10:00:53 AEDT ]]> Therapeutic Targeting of the Respiratory Microbiome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51767 Mon 18 Sep 2023 14:30:18 AEST ]]> 2-Methylhopanoids in geographically distinct, arid biological soil crusts are primarily cyanobacterial in origin https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45745 Fri 04 Nov 2022 10:19:57 AEDT ]]>